Skin ageing is a gradual process perceived by changes in the appearance and texture of the skin.These changes are a consequence of the passing of time (chrono aging or intrinsic aging), exposure to solar radiation (photoaging), lifestyle and other environmental or external factors.

Thus, skin aging does not always match the chronological age, but reflects the skins biological age.According to the aging scientific approach defined by Dr. Glogau, skin aging can be classified in 4 degrees that gradually reflect the intensity of the epidermal and dermal damage.

The 4 degrees of aging should be treated differently and gradually. As a result, Mesoestetic® has different specific products for preventative to corrective solutions in order to answer each skin need.

Please note: Add Ons’ are important to achieve the dire you’re after.

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Mesoestetic Energy C Treatment

Vitamin C (ascorbic acid) is an active substance that prevents skin aging. Applied topically, it remains on the skin for up to 48 hours for a therapeutic response that is 30 times higher than with oral administrations.

Its efficacy has been proven in several in vitro and vivo studies that confirm the following properties:

Antioxidant – Topically applied vitamin C gives a dual antioxidant action: it neutralizes free radicals of cells by providing electrons and participates in the regeneration of Vitamin E, which is essential for protecting the lipid membrane cells. In Vitro studies subjecting Energy C intensive cream and Energy C Eye Contour to free radicals (DPPH) for 30 minutes have demonstrated the high antioxidant capacity of vitamin c, up to 76% (depending on the concentration and combinations thereof).

UVA AND UVB PHOTOPROTECTOR Regarding the neutralisation of free radicals, vitamin c fulfills an action of prevention and soothing the oxidating damage of ultraviolet radiation in epidermal cells. Applied before sun exposure, vitamin c acts as a biological photoprotector. After exposure, its anti-inflammatory action enables reducing post-sun erythema.

BRIGHTENER Vitamin C is an effective whitening agent. It brightens the face and improves pigmentary damage of several origins (melasma, post-acne, etc.) Upon neutralising copper, it inactivates tyrosinase, which activates a preventive action on the formation of hyperpigmentation’s.

COLLAGEN SYNTHESIS BOOSTER Topical vitamin c induces the production of procollagen I and III, precursors of dermal collagen. Studies have demonstrated that topical application of vitamin c increases the number of elastic fibroblasts, thereby improving the quality of the extracurricular matrix and providing moisture, which fights the appearance of expression lines and fine wrinkles. Studies show that topical application of energy c products increases collagen synthesis up to 3.5 times. Stage I – Energy C Range MODIFICATIONS – Increase in oxidative processes and the action of free radicals. – Increase in the loss of transepidermal water and reduction of amino acid and protein levels. – Weakening of the cell barrier.

CONSEQUENCES – Increase in skin opacity. – First expression lines. – Fine wrinkles.

Mesoestetic Collagen 360 Treatment

Collagen is the most abundant protein in the skin (70%) and represents the 25% of the body proteins, being the main component of the extracellular matrix (support structure). Its function is to ensure the mechanical resistance and firmness of the dermis. Over time causes a reduction in collagen synthesis, an increase in its degradation and a disruption in its fibers.

Collagen is the main component of the essential substance of the dermis. Both skin thickness and tensile strength of the dermis depend on collagen synthesis. Enriched marine collagen shows full compatibility with skin cells which enables them to act on two fronts:

By supply of structural unit: the amino acids contained are used as a dermis substrate to form new collagen.

By stimulation of cells involved in collagen synthesis: fibroblasts react to the presence of free amino acids reactivating collagen production.

Studies show that the enriched marine collagen contained in collagen 360 intensive cream increases tissue stimulation of fibroblasts (+37%0, thereby inducing the formulation of new collagen (+69%) and promoting elastin synthesis (+37%). It redensifies and gives the dermis firmness, which improves tissue elasticity.

MODIFICATIONS – Reduction in the capacity of fibroblasts synthesis, that results in a reduction of collagen fibres and elastin levels.

Reduction in the quantity and quality of the skin structural elements which are a part of the support structure of the dermis (fundamental substance).

CONSEQUENCES – Reduction of the dermis thickness that results in a loss of skin firmness. – Increase of deeper wrinkles.

Mesoestetic Stem Cell Treatment

These are progenitor cells that are auto renewable by means of mitosis and can regenerate one or more kinds of differentiated cells. There are adult stem cell populations in the various tissues responsible for periodic renewal and regeneration and repair when damage occurs in them (acting as cell reserve). Stem cells can divide, without losing their properties, and generate new cells. They are the mainstay for the cell renewal process, so their protection and restoring is essential. For each protected stem cell, thousands of epidermal cells may be renewed, repairing the effects of skin aging.

Skin stem cells are the direct precursors of the cells found in the different dermal layers. Thanks to their ability to differentiate, they can regenerate aged tissues. The plant stem cells extract is obtained by means of a biotechnology process. It is characterised by being rich in phytonutrients and proteins. Several clinical trials performed with this active substance have revealed the following properties:

Cell regeneration and repair – The plant stem cells extract has the ability to effectively protect and reactivate our own dermoepidermal stem cells, strengthening the connective tissue structure and improving skin quality and texture. Deep antiwrinkles – By stimulating fibroblast and keratinocyte activity in the production of collagen and elastin, the plant stem cell extract plays a strong antiaging and anti-wrinkle effect on skin.

Stage III – Stem Cell Range MODIFICATIONS – Reduction of the number of cells in a maturation stage which are responsible for the skin structures (slowing down of cell renewal). – Loss of efficiency of the metabolic processes which influences normal skin deterioration. – Deterioration of the external epidermis layers and reduction of the quality of the skin support tissue.

CONSEQUENCES – Gradual decrease of skin elasticity together with lack of firmness. – Deep wrinkles.

Mesoestetic Radiance DNA Treatment

This treatment is designed to respond to Stage IV aging aesthetics disorders and aims to increase cell longevity, acting on DNA repair and protection processes. For best results, we recommend using the Radiance Dna home care product range.

Stage IV – Radiance DNA Range MODIFICATIONS – Destructuring of intercellular junctions of the external skin layers. – Reduction and loss of metabolic function of the oil and sweat glands. – Hyperkeratination of the stratum corneum (rough to touch) CONSEQUENCES – Loss of definition of the facial contour. – Increase of skin fragility. – Very deep wrinkles